B6 and b12 and breast cancer

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Vitamin B6, also known as pyridoxine or pyridoxal phosphate, is an important component of folate metabolism. B6 is part of the pathway that produces a supply of methionine to serve as a main donor for active methyl groups and components for DNA synthesis and repair. It is hypothesized that the deficit or surplus of vitamin B6, as well as other B vitamins, may play a role in carcinogenesis and may therefore be a target for chemoprevention or antitumor activity.

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Vitamin B12 is an essential vitamin. This means that the body requires vitamin B12 to work properly. Vitamin B12 can be found in foods such as meat, fish, and dairy products.

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People with a genetic mutation linked to cancer risk. Rating Details. Printer Friendly Page.

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This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Users of this Web site should not rely on information provided on this Web site for their own health problems. Any questions regarding your own health should be addressed to your own physician or other healthcare provider.

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Vitamin B6 is a type of B vitamin. It can be found in certain foods such as cereals, beans, vegetables, liver, meat, and eggs. It can also be made in a laboratory.

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Skip to search form Skip to main content. Medicine Published in Journal of the National…. However, data relating plasma folate levels to breast cancer risk are sparse.

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Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer BC risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. After a mean follow-up of

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New research suggests long-term, high-dose supplementation with vitamins B6 and B12 -- long touted by the vitamin industry for increasing energy and improving metabolism -- is associated with a two- to four-fold increased lung cancer risk in men relative to non-users. Risk was further elevated in male smokers taking more than 20 mg of B6 or 55 micrograms of B12 a day for 10 years. Male smokers taking B6 at this dose were three times more likely to develop lung cancer.

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Metrics details. Several studies have determined that dietary intake of B vitamins may be associated with breast cancer risk as a result of interactions between 5,methylenetetrahydrofolate reductase MTHFR and methionine synthase MTR in the one-carbon metabolism pathway. However, the association between B vitamin intake and breast cancer risk in Brazilian women in particular has not yet been investigated.

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B vitamins, including vitamin B 6are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis. We examined the association of dietary vitamin B 6 intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included breast cancer cases and control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan.

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