A small number of genetic conditions are linked to an increased risk of pancreatic cancer. These are sometimes called family cancer syndromes. Most family cancer syndromes are linked to pancreatic ductal adenocarcinomathe most common type of pancreatic cancer.
Skip to Content. Use the menu to see other pages. Although risk factors often influence the development of cancer, most do not directly cause cancer.
Tom, a Chandler resident, is cancer free at But he has a family health history marked by cancer: His grandmother, four aunts and two first cousins have all passed away from various forms of cancer on the maternal side. And six first cousins on Tom's mother's side have been diagnosed with cancer.
Pancreatic cancer is notorious for being difficult to treat —and it is often not detected until it advances beyond the pancreas. While smoking and obesity are two established risk factors that impact this disease, another risk factor can be mutations in the BRCA2 gene, also associated with breast and ovarian cancer. Research studies have identified a link between mutations in the BRCA2 gene and pancreatic cancermeaning that individuals who test positive for a BRCA2 BReast Cancer susceptibility gene mutation demonstrate a heightened risk of pancreatic cancer.
In the fight against pancreatic cancer, clinical trials often provide the best treatment options. Callemail info pancan. This can affect both men and women.
Donate Shop. Pancreatic cancer occurs when malignant cells develop in part of the pancreas. This may affect how the pancreas works, including its exocrine or endocrine functions.
A new prospective study of patients with Lynch syndrome — an inherited disorder of cancer susceptibility caused by mutations in specific DNA repair genes — provides the first strong evidence that people with Lynch syndrome face significantly increased risks of breast and pancreatic cancers. The study also provided new, clearer estimates of the risks of cancers already recognized to be associated with Lynch syndrome, including those of the colon, uterus, ovary, kidney, stomach and bladder. The findings — published February 13 in the Journal of Clinical Oncology — may have implications for screening and early detection of cancers in patients with the condition.
Synchronous cancers have occasionally been detected at initial diagnosis among patients with breast and ovarian cancer. However, simultaneous coexistence and diagnosis of breast and pancreas cancer has not previously been reported. Paternal transmission of a germline BRCA2 mutation to a patient who was diagnosed at age 40 with locally advanced breast and pancreas cancer is presented. Somatic genomic analysis of both cancers with next-generation DNA sequencing confirmed the germline result and reported a variety of variants of unknown significance alterations, of which two were present in both the breast and pancreas cancers.
Genetics may play a larger role in pancreatic cancer than previously thought, an expert panel has found. Stoffel, who was part of the expert panel that developed the new recommendation, explains what it means for patients and families:. Stoffel: It calls for all patients diagnosed with pancreatic cancer to receive genetic counseling related to their risk for inherited syndromes associated with an increased risk for pancreatic cancer.