Genetics and breast cancer

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Mutations in these genes have been linked to a higher risk of breast cancer and ovarian cancer. Cancer is also more likely to develop at an earlier age. A genetic counselor can help you understand if you're likely to have an inherited susceptibility to breast or ovarian cancer.

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Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts ductal cancer.

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Skip to Content. The chance that a family has HBOC increases in any of these situations:. A woman is diagnosed with a second breast cancer in the same or the other breast or has both breast and ovarian cancer.

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Breast cancer in families 2. How does breast cancer start? What causes breast cancer? If you or one of your close relatives has been diagnosed with breast cancer, you may have concerns about whether breast cancer runs in the family sometimes called hereditary breast cancer.

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People who inherit mutations in these genes are at an increased risk of developing breast cancer and ovarian cancer compared with the general population. The BRCA gene test is offered to those who are likely to have an inherited mutation based on personal or family history of breast cancer or ovarian cancer. The BRCA gene test isn't routinely performed on people at average risk of breast and ovarian cancers.

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A family history of breast cancer means having one or more blood relatives who have, or have had, breast cancer. As breast cancer is common, many women will have a family history by chance. However, some women with a family history may have inherited a faulty gene which increases the risk of cancer.

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Find information and resources for current and returning patients. Learn about clinical trials at MD Anderson and search our database for open studies. The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services.

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When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer. People who have inherited mutations in BRCA1 and BRCA2 tend to develop breast and ovarian cancers at younger ages than people who do not have these mutations.

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If you have close relatives with breast or ovarian cancer, you may be at higher risk for developing these diseases. Does your family health history put you at higher risk? Would you benefit from cancer genetic counseling and testing?

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Genes are short segments of DNA deoxyribonucleic acid found in chromosomes. DNA contains the instructions for building proteins. And proteins control the structure and function of all the cells that make up your body.

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